Question:
Can Chilkat be used to read or send email using Office 365 or Microsoft Exchange?
Yes, Office 365 and Exchange can (and do) provide the standard protocols for sending and reading email (SMTP, POP3, and IMAP). An app could connect to an Exchange Server or Office 365 in the same way as any other mail server.
For example, here are POP, SMTP, and IMAP settings for Office 365:
Office 365 IMAP Settings
Server name: outlook.office365.com
Port: 993
SSL/TLS: TLS* v1-1.2 (implicit)
Office 365 POP Settings
Server name: outlook.office365.com
Port: 995
SSL/TLS: TLS* v1-1.2 (implicit)
Office 365 SMTP Settings
Server name: smtp.office365.com
Port: 587
SSL/TLS: TLS* v1-1.2 (explicit -- i.e. StartTLS)